Table 1 Cellular activity similarities between eRNA and NamiRNA
From: Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis
Activities | eRNA | miRNA | ||
|---|---|---|---|---|
Cytoplasm | Nucleus | Cytoplasm | Nucleus | |
Cellular stage of operation | No evidence yet | Pre-transcription | Post-transcription | Post-transcription, transcriptional |
Location | No evidence yet | Yes | Yes | Yes |
Target | No evidence yet | Promoter sequence [44], enhancers [9], DNA [45], lncRNA, and other ncRNA [67] | mRNA [68] | |
Transcriptional effect | No evidence yet | Activation [54] | Activation [3] | |
Mode of action | No evidence yet | RNA–RNA hybrid RNA–DNA-DNA hybrid [45] | RNA-RNA hybrid [69] | RNA–RNA hybrid RNA–DNA hybrid RNA–DNA–DNA hybrid [69] |
Cis and trans activities | No evidence yet | Yes [67] | No evidence yet | Yes [70] |
Transcriptional activity | No evidence yet | Yes | Yes | Yes |
Activation of genes/mRNA | No evidence yet | Yes [48] | No | Yes |