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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling

Fig. 4

Ferroptosis was responsible for the effects of ATF3 up-regulation on cisplatin resistance. Cisplatin-resistant GC cells (SGC7901/DDP and BGC823/DDP) were treated with ATF3 transfection, ferroptosis agonist erastin, RSL3 and antagonist liproxstatin-1 under cisplatin conditions. Then, the levels of ROS (A), MDA (B), lipid peroxidation (C) and GSH (D) were determined. E, F Cell viability in SGC7901/DDP (E) and BGC823/DD (F) was evaluated by CCK-8 assay. *P < 0.05 vs. control group. §P < 0.05 vs. ATF3-treated group

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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