Fig. 7

MYO6 is a downstream target of miR-145. A Binding sites between MYO6 and miR-145 were predicted by TargetScan 7.2. B Dual-luciferase reporter assays of GC cells co-transfected with WT/MUT MYO6 and miR-145 mimics or miR-NC. C Box plot data about UCA1 expression were obtained from TCGA and GTEx databases. D Q-PCR showing MYO6 expression level in GC cell lines and tissues. E Western blot showing MYO6 expression level in GC tissues and cell lines. F IHC showing MYO6 expression level in GC tissues. G Scatter diagram showing a positive correlation of UCA1 and MYO6 in GC tissues by Q-PCR. H Scatter diagram showing a negative correlation of miR-145 and MYO6 in GC tissues by Q-PCR. *p < 0.05, compared with control cells or tissues