The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation

Table 1 Histone acetylation and modulation of molecules in Wnt/β-catenin signaling

Histone modifier	Histone modification	Target gene	Effect on target genes	Target cells or models	References
GCN5	H3K9Ac	Wnt1	Activation	BMSCs	[59]
GCN5	H3K9Ac	Wnt10a	Activation	BMSCs	[59]
GCN5	H3K9Ac	Wnt6	Activation	BMSCs	[59]
GCN5	H3K9Ac	Wnt10b	Activation	BMSCs	[59]
HDAC1	unknown	β-catenin	Inhibition	MEFs	[60]
P300	H3K27Ac	FZD3	Activation	Alzheimer’s disease mouse model	[61]
SIRT6	H3K9Ac	FZD4	Inhibition	Hepatoblastoma cells	[62]
HDAC3	unknown	WIF-1	Inhibition	Fibroblasts	[63]
HDAC1	H3Ac	SFRP1	Inhibition	HCC cells	[64]
SIRT1	H3K9Ac	SFRP1	Inhibition	MEFs	[38]
SIRT1	H4K16Ac	SFRP1	Inhibition	MEFs	[38]
SIRT1	H3K9Ac	SFRP2	Inhibition	MEFs	[38]
SIRT1	H4K16Ac	SFRP2	Inhibition	MEFs	[38]
HDAC1	H3Ac	DKK1	Inhibition	Breast cancer cells	[66]
HDAC2	H3Ac	DKK1	Inhibition	Breast cancer cells	[66]
HDAC1	H4Ac	DKK1	Inhibition	Breast cancer cells	[66]
HDAC2	H4Ac	DKK1	Inhibition	Breast cancer cells	[66]
GCN5	H3K9Ac	DKK1	Activation	Periodontal ligament stem cells	[67]
GCN5	H3K14Ac	DKK1	Activation	Periodontal ligament stem cells	[67]
p300	H3Ac	DKK1	Activation	Breast cancer cells, HCC cells,	[68, 70]
CBP	H3Ac	DKK1	Activation	Breast cancer cells	[68]

ISSN: 1689-1392