Skip to main content
Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

Fig. 2

Knockdown METTL3 expression inhibits Ang-II-induced cardiomyocyte hypertrophy. A qRT-PCR detected the expression of METTL3 in Ang-II-induced NRCMs transfected with shMETTL3. n = 3. B Western blot detected the expression of METTL3 in Ang-II-induced NRCMs transfected with shMETTL3. n = 3. C Assay detected m6A modification of total RNA in Ang-II-induced NRCMs transfected with shMETTL3. n = 3. D qRT-PCR detected the expression of biomarkers ANP and BNP in Ang-II-induced NRCMs transfected with shMETTL3. n = 3. E Western blot detected the expression of biomarkers ANP and BNP in Ang-II-induced NRCMs transfected with shMETTL3. n = 3. F NRCMs were transfected with shMETTL3, followed by Ang-II stimulation. Representative immunohistochemistry images of NRCMs stained with α-actinin in green. The nucleus is stained in blue. Scale bars represent 10 μm. The cell surface area was evaluated. n = 3. *P < 0.05, **P < 0.01, ***P < 0.001

Back to article page

Cellular & Molecular Biology Letters

ISSN: 1689-1392

Contact us