Fig. 6

Effect of AT on the treatment of OA in vivo. A and B Histological sections from knees (n = 6) stained with HE and Safranin-O and associated OARSI scores. C and D Immunohistochemical staining of ATG5. Immunohistochemical staining of MMP3 and quantification of IHC scores. E Micro-CT was performed to scan the morphology of the knee joint. Normal group (injected with 0.1 mL PBS, n = 5), OA model group (injected with 0.1 mL PBS, n = 5), OA + AT group (injected with 0.1 mL of AT, 20 μm, n = 5); values are presented as mean ± SD (n = 5), *** P < 0.001