Fig. 6

Administration of miR-92a-2-5p improved cardiac remodeling and function in diabetic rats. A Detection of random blood glucose level in diabetic rats injected with the miR-92a-2-5p agomiR. n = 10 in each group. B Representative echocardiographic images of the diabetic rat hearts from NC and miR-92a-2-5p agomiR groups. C-G Evaluation of the mean values of EF, FS, LVAWs, LVPWs, and LVIDs in diabetic rats. n = 10 in each group. *P < 0.05, and **P < 0.01. H Determination of heart weight/body weight (HW/BW) ratio in diabetic rats from the NC and miR-92a-2-5p agomiR groups. n = 10 in each group. **P < 0.01. I Representative images of H & E staining of rat hearts from NC and miR-92a-2-5p agomiR groups. J Representative images of Masson’s staining in rat left ventricle tissues from the NC and miR-92a-2-5p agomiR groups. Scale bar = 50 μm. K-L Detection of protein carbonyl levels and superoxide dismutase (SOD) activity in the heart tissues from the NC and miR-92a-2-5p agomiR groups. n = 10 in each group. *P < 0.05, and **P < 0.01. M Representative images of immunohistochemistry (IHC) for 8-OHdG in rat left ventricle tissues from the NC and miR-92a-2-5p agomiR groups. Scale bar = 20 μm