Table 2 Immunomodulatory drugs that target macrophage polarization
From: The role of macrophage subtypes and exosomes in immunomodulation
immunomodulatory drugs | Functions | References |
|---|---|---|
Thapsigargin | Promote M2 polarization | [95] |
Glucocorticoids | Trigger M2 polarization | [96] |
Azithromycin | Promotes polarization from M1 to M2 | [97] |
5-Aminosalicylates (5-ASAs) | Inhibitory role in macrophage activation and inflammation suppressor | [98] |
[6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine] | Repressed nitric oxide synthase (iNOS) expression | [99] |
Imiquimod | Restore pro-inflammatory of TAMs | [100] |
PLX3397, PLX108-01 (pexidartinib) | Deplete macrophages | |
Trabectedin | Deplete macrophages | [104] |
CP-690,550 (tofacitinib) | Inhibit modulate gene expression in macrophages | [105] |
Hyaluronic acid oligosaccharides | Modulate macrophage polarity | [106] |
Tocilizumab | M1 macrophage suppression |