Table 7 Functional characterization of PVT1 in urinary system tumors
Tumor type | Expression | Role | Function role | miRNAs | Related genes | References |
|---|---|---|---|---|---|---|
Renal cell carcinoma | Upregulation | Oncogene | Apoptosis | / | EGFR/AKT/MYC | [173] |
Renal cell carcinoma | Upregulation | Oncogene | Apoptosis | / | Mcl-1 | [174] |
Renal cell carcinoma | Upregulation | Oncogene | Proliferation, migration, invasion, and angiogenesis | / | HIF2α | [175] |
Renal cell carcinoma | Upregulation | Oncogene | Proliferation and invasion | miR-200s | BMI1, ZEB1 and ZEB2 | [179] |
Renal cell carcinoma | Upregulation | Oncogene | Proliferation, invasion, and EMT | miR-16-5p | / | [180] |
Bladder cancer | Upregulation | Oncogene | Proliferation, migration, and invasion | miR-31 | CDK1 | [184] |
Bladder cancer | Upregulation | Oncogene | Proliferation and migration | miR-128 | VEGFC | [185] |
Bladder cancer | Upregulation | Oncogene | Proliferation,migration, and apoptosis | miR-194-5p | BCLAF1 | [186] |
Bladder cancer | Upregulation | Oncogene | Proliferation,invasion, apoptosis, and chemoresistance | / | Wnt/β-catenin | [187] |
Prostate cancer | Upregulation | Oncogene | Growth | / | c-Myc | [189] |
Prostate cancer | Upregulation | Oncogene | EMT | miR-186 | Twist1 | [190] |
Prostate cancer | Upregulation | Oncogene | Proliferation and migration | / | P38 | [191] |
Prostate cancer | Upregulation | Oncogene | Metastasis | / | NOP2 | [192] |
Prostate cancer | Upregulation | Oncogene | Migration and invasion | miR-15a-5p | KIF23 | [193] |
Prostate cancer | Upregulation | Oncogene | Growth | miR-146a | / | [194] |