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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: Exosomal miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression

Fig. 7

M1-Exo regulated the circFUT8/CHMP4B axis via METTL14 to inhibit HCC cell progression. A–C The proliferation and apoptosis of HCC cells in different groups transfected with sh-NC, sh-circFUT8#1, and sh-circFUT8#1 + CHMP4B plasmids was verified through colony formation together with EdU and flow cytometry assays. D–F HCC malignant cell behaviors were evaluated through functional assays in different groups (control, Exo, Exo + METTL14, Exo + METTL14 + sh-circFUT8#1, and Exo + METTL14 + sh-circFUT8#2). In relevant assays, data in the experimental group was statistically significant in comparison with the negative control group (P < 0.01)

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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