Fig. 2

Protective effect of melatonin pretreatment in septic mice. a Kaplan–Meier survival curves. Twelve animals for each group were used for comparison. Mortality was observed within 72 h. b Sepsis scores (n = 6 for each group). c Anal temperature (n = 7 for each group). d Blood routine parameters (n = 6 for each group). e Blood biochemical parameters (n = 6 for each group). ^*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus sham or versus CLP; ns, nonsignificant. Statistical analysis of data was performed using ANOVA