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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Fig. 3

eNOS uncoupling due to diminished L-Arg/ADMA ratio. Under reduced L-Arg availability (resulting from excessive arginase activity) and/or accumulation of ADMA (due to decreased DDAH activity), the substrate concentration may not be sufficient to saturate eNOS and/or L-Arg is outcompeted by ADMA. As a result, molecular oxygen is a final electron acceptor, leading to superoxide formation

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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