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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Fig. 5

Major causes of eNOS uncoupling as targets of potential therapeutic interventions. Oxidative stress associated with cardiovascular risk factors leads to eNOS uncoupling by: A decreased BH4/BH2 ratio due to oxidation of BH4 and impairment of DHFR expression/activity; B decreased L-Arg/ADMA ratio due to excessive arginase expression/activity and diminished DDAH expression/activity; C eNOS S-glutathionylation at Cys689 and Cys908

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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