Fig. 10
TGF-β-IRE1α signaling inhibits immunological characteristics of muscle cells by attenuating p38 MAPK pathway. Western blot analyses of the expression changes of H-2Kb, H2-Eα, or TLR3 in MPC-myotubes derived from Con and SM TGF-βr2−/− mice (A), or in TGF-βr2−/− MPC-myotubes (B) with or without stimulation of IFN-γ/LPS, SRI, 4μ8C, and/or SB (p38 pathway inhibitor). The relative protein expression values are expressed as a ratio (protein of interest/GAPDH). All data are presented as means ± SD (n = 3). A one-way ANOVA was used for multiple comparisons (*P < 0.05; **P < 0.01)