Fig. 6

Intrinsic TGF-β signaling effects on the activities of IRE1α and eIF2α arms of UPR in muscle cell. A The protein levels of IRE1α and eIF2α in damaged TA muscle from control or SM TGF-βr2^−/− mice were analyzed by Western blot. The relative protein expression values are expressed as a ratio [phosphorylated (P) protein/total (T) protein]. B Immunofluorescence staining and the quantitative results of IRE1α and eIF2α in damaged TA muscle. All data are presented as means ± SD (n = 3). A one-way ANOVA was used for multiple comparisons (*P < 0.05; **P < 0.01). Bar = 50 μm