Fig. 1

miR-3613-3p knockdown recovered BMEC proliferation, migration, and angiogenesis in OGD-treated BMECs. A Five miRNAs that prominently changed in the OGD-treated BMEC exosomes based on miRNA GeneChip assay were also confirmed to have prominently changed in the OGD-treated BMEC exosomes on the basis of RT-qPCR. Differences were analyzed using t-test. *P < 0.05. B miR-3613-3p expression in BMECs were measured by qRT-PCR after transfection at 24 h and treated for 4 h. C BMEC proliferation was measured by MTS, and the survival was calculated according to the percentage of the test group/control group (normal-BMECs group). D, E The bar represents the migration rate and angiogenesis (include total number of meshes/nodes and branching/segments length), respectively. F, G Representative image of the migration rate and angiogenesis after transfection at 48 h, followed by OGD treatment for 4 h. Differences were analyzed using ANOVA, followed by post-hoc Dunnett’s multiple comparisons test. *p < 0.05.