Fig. 8

TMEM30A deletion led to increased ER stress and UPR in cochleae. a CHOP was absent in organ of Corti in WT mice by immunofluorescence staining on frozen section, but was accumulated in KO mice at P7. Quantitative analysis suggested about ten-fold increase of CHOP expression in KO cochleae. Red CHOP, blue, DAPI (b). c, d Western blotting of Bip protein indicated a five-fold increase in KO cochlea. Scale bar, 15 µm. Error bars indicate the standard error of the mean. In b, N = 8. In d, N = 3