Table 1 The role of STAT3 in regulating autophagy in HCC

ROS/STAT3/autophagy

Suppression of ROS /STAT3/autophagy promotes induction of apoptosis in HCC cells

[88]

AKR1C/JAK2/STAT3

Downregulation of AKR1C leads to inhibition of the JAK2/STAT3 axis to suppress autophagy in impairing tumorigenesis

[89]

JAK2/STAT3/autophagy

Bufothionine promotes ATGs and Beclin-1 in autophagy induction by inhibiting JAK2/STAT3 signaling to reduce tumorigenesis

[90]

MARCH1/STAT3/autophagy

Upregulation of MARCH1 stimulates STAT3 signaling to mediate autophagy

[91]

SOCS3/JAK1/STAT3

Dimethyl fumarate increases SOCS3 expression to inhibit the JAK1/STAT3 axis and suppress autophagy in HCC therapy

[92]

JAK2/STAT3/autophagy

Inhibition of JAK2/STAT3 suppresses autophagy and promotes oxaliplatin-mediated apoptosis in HCC cells

[95]