Table 2 The regulation of EMT mechanism by STAT3 in HCC cells
Signaling network | Remark | Reference |
|---|---|---|
MiR-345/mTOR/STAT3/Akt | MiR-345 reduces the expression of IRF1 to suppress the mTOR/STAT3/Akt axis in inhibiting EMT | [222] |
ERO1α/S1PR1/STAT3/VEGF-A | ERO1α increases the expression of S1PR1 to induce STAT3/VEGF axis in angiogenesis induction and EMT stimulation | [223] |
DLGAP1-AS1/miR-26a/b-5p/IL-6/JAK2/STAT3 | Downregulation of miR-26a/b-5p by DLGAP1-AS1 to induce STAT3 signaling and mediate EMT | [224] |
STAT3/NFE2L1/STX12 | Mitochondrial respiratory defect leads to STAT3 upregulation to induce NFE2L1/STX12 axis in EMT induction and facilitate tumor invasion | [225] |
TLX3/STAT3/SNAI1/EMT | TLX3 reduces STAT3 expression to suppress SNAI1-mediated EMT | [226] |
B7-H3/JAK2/STAT3/Slug | B7-H3 induces the JAK2/STAT3 axis to increase Slug expression upon EMT induction | [227] |
KIAA1217/STAT3/EMT | KIAA1217 stimulates EMT mechanism via STAT3 upregulation to increase cancer progression | [228] |
FEZF1-AS1/JAK2/STAT3 | FEZF1-AS1 stimulates the JAK2/STAT3 axis during EMT induction | [229] |
IL-35/STAT3/EMT | IL-35 promotes STAT3 expression to stimulate EMT | [230] |
RBM3/STAT3/EMT | RBM3 promotes STAT3 expression to induce EMT | [231] |
Glycochenodeoxycholic acid/STAT3/EMT | Up-regulation of STAT3 to induce EMT | [232] |
STAT3/Snail/EMT | High expression level of Oct4 and Nanog promotes STAT3 expression to upregulate Snail in inducing EMT | [233] |
STAT3/CASC11/PTEN/PI3K/Akt | STAT3 increases CASC11 expression to induce PI3K/Akt signaling via PTEN down-regulation upon EMT induction | [234] |
IL-6/STAT3/HIF-1α/SNAI1/EMT | IL-6 promotes STAT3 expression to upregulate HIF-1α Up-regulation of SNAIL1 to induce EMT | [235] |
DSCR8/miR-98-5p/STAT3/HIF-1α | DSCR8 promotes STAT3 expression via miR-98-5p sponging to increase HIF-1α expression and induce EMT, which enhances cancer invasion | [236] |
STAT3/Twist/EMT | STAT3 increases the expression of Twist to stimulate EMT | [237] |
TRIM27-USP7/STAT3/EMT | TRIM27-USP7 promotes STAT3 expression during EMT induction | [238] |
STAT3/EMT | STAT3 stimulates EMT during increasing HCC invasion | [239] |