Table 4 The role of noncoding RNAs in the regulation of STAT3 signaling in HCC
Molecular pathway | Remark | Reference |
|---|---|---|
MiR-486-5p/IGF-1R/STAT3 | MiR-486-5p reduces IGF-1R expression to suppress STAT3 signaling | [252] |
MiR-MTCO3P38/STAT3/PTTG1/MYC | Inhibition of STAT3 signaling and downstream targets by miR-MTCO3P38 | [253] |
MiR-363/S1PR1/STAT3 | MiR-363 reduces S1PR1 expression to inhibit STAT3 signaling | [254] |
Gα12/miR-122/c-Met/STAT3 | Gα12 decreases miR-122 expression through HNF4α | [255] |
LINC01133/miR-199a-5p/annexin A2 | c-Met induction to stimulate STAT3 signaling | [256] |
Circ-0006916/miR-337-3p/STAT3 | LINC01133 promotes the expression of annexin A2 via miR-199a-5p to induce STAT3 signaling | [194] |
LINC01433/miR-1301/STAT3 | Circ-0006916 promotes STAT3 expression via miR-337-3p sponging in tumorigenesis | [257] |
MiR-337-3p/JAK2/STAT3 | LINC01433 promotes STAT3 expression via inhibition of miR-1301 | [258] |
MiR-137/EZH2/STAT3 | MiR-337-3p suppresses the JAK2/STAT3 axis in affecting HCC progression | [259] |
MiR-30e/JAK1/STAT3 | MiR-137 reduces EZH2 expression and inhibits STAT3 signalingmiR-30e inhibits the JAK1/STAT3 axis in suppressing carcinogenesis | [260] |
LINC01287/miR-298/STAT3 | LINC01287 induces STAT3 via downregulation of miR-298 in EMT induction | [261] |
SNHG16/miR-4500/STAT3 | SNHG16 increases STAT3 expression via miR-4500 sponging in tumorigenesis | [262] |
MiR-500a-3p/STAT3 | MiR-500a-3p stimulates STAT3 signaling in cancer stemness enhancement | [263] |
Circ-LRIG3/EZH2/STAT3 | Circ-LRIG3 increases STAT3 expression in an EZH2-dependent manner to promote tumorigenesis | [264] |
MiR-506/STAT3 | MiR-506 suppresses STAT3 signaling to enhance natural killer cell cytotoxicity | [265] |
MiR-146a | STAT3 promotes miR-146a expression in inhibiting anti-tumor immune response | [266] |
NEAT1/miR-485/STAT3 | NEAT1 sponges miR-485 to induce STAT3 signaling | [267] |
MiR-451/IL-6R/STAT3 | MiR-451 suppresses STAT3 signaling to inhibit angiogenesis via lower VEGF expression | [268] |
MiR-515-5p/IL-6/JAK/STAT3 | MiR-515-5p inhibits STAT3 signaling in reducing HCC progression | [269] |
MiR-135a-5p/PTPRD/STAT3 | MiR-135a-5p induces STAT3 signaling via downregulating PTPRD to promote tumorigenesis | [270] |
Circ-0072088/miR-375/STAT3 | Circ-0072088 increases STAT3 expression via miR-375 sponging to enhance cancer progression | [197] |