Table 5 The antitumor compounds targeting STAT3 signaling in HCC therapy
Compound | Molecular pathway | Remark | Reference |
|---|---|---|---|
18-Glycyrrhetinic acid | STAT3/EMT | Inhibition of STAT3 signaling to suppress TGF-β-mediated EMT | [271] |
LBH589 | Gankyrin/STAT3/Akt | Reduction of proliferation and invasion by inhibition of the gankyrin/STAT3/Akt axis | [272] |
Atorvastatin | IL-6/STAT3 | Inhibition of the IL-6/STAT3 axis to induce senescence in tumor cells | [273] |
Scutellarin | JAK2/STAT3 | Inhibition of the JAK2/STAT3 axis to reduce cancer progression | [274] |
Carnosic acid | STAT3 ERK1/2 | Downregulation of STAT3 and ERK1/2 to suppress proliferation and invasion | [275] |
Atiprimod | STAT3/NF-kB/apoptosis | Inhibition of the STAT3/NF-kB axis in the stimulation of apoptosis | [276] |
Brusatol | STAT3/EMT | Inhibition of EMT by reducing STAT3 expression | [277] |
Norcantharidin | JAK2/STAT3/TWIST | Inhibition of STAT3 signaling to reduce TWIST expression and suppress EMT | [278] |
Sorafenib | TLR3/STAT3/SUMO1 | Sorafenib reduces caspase-1 expression via suppression of the TLR3/STAT3/SUMO1 axis | [279] |
ZnAS@SiO2 nanoparticles | SHP-1/JAK2/STAT3 | Inhibition of STAT3 signaling to suppress EMT and reduce stemness | [280] |
Hemistepsin a | STAT3 | Inhibition of STAT3 to mediate apoptosis | [281] |
Selenium sulfide | PLAGL2/C-MET/STAT3 | Selenium sulfide inhibits the C-MET/STAT3 axis in a PLAGL2-dependent manner to induce apoptosis in tumor cells | [282] |
Kahweol | Src/mTOR/STAT3 | Kahweol inhibits the Src/mTOR/STAT3 axis in apoptosis induction | [283] |
Sinomenine | AMPK/STAT3 | Suppression of HCC progression through inhibition of the AMPK/STAT3 axis | [284] |
Dihydrotanshinone | JAK2/STAT3 | Inhibition of the JAK2/STAT3 axis in interfering with tumorigenesis | [285] |
Isoliquiritigenin | ROS/MAPK/STAT3/NF-kB | Regulation of STAT3 signaling in a ROS-dependent manner to stimulate apoptosis in tumor cells | [286] |
Liraglutide | IL-6/STAT3 | Inhibition of STAT3 signaling to enhance antitumor immune response | [287] |
Xanthin analog | ROS/JAK2/STAT3 | Inhibition of STAT3 signaling in a ROS-dependent manner to stimulate apoptosis | [288] |