Table 4 Studies regarding blood-based exosomes as potential biomarkers for bladder cancer
Authors (year) | Sample type | Functional component | No. of patients | Laboratory technique | Clinical application | Detection rate | Refs. |
|---|---|---|---|---|---|---|---|
Wang et al. (2018) | Serum | H19 | 104 | ExoQuick exosome purification kit | Diagnostic biomarker | AUC = 85.1%, sensitivity = 74.07%, specificity = 78.8% | [157] |
Zhang et al. (2019) | Serum | Three-lncRNA panel (PCAT-1, UBC1, and SNHG16) | 520 | ExoQuick exosome purification kit | Diagnostic biomarker | AUC = 0.857 in training set, and 0.826 in validation set | [158] |
Xue et al. (2017) | Serum | lncRNA-UCA1 | 60 | ExoQuick exosome purification kit | Diagnostic biomarker | AUC = 87.83%, sensitivity = 80%, specificity = 83.33% | [159] |
Elsharkawi et al. (2019) | Serum | Tumor-derived exosomes | 82 | ExoQuantTM overall exosome capture and quantification assay kit, ELISA | Diagnostic biomarker | Sensitivity = 82.4%, specificity = 100% | [160] |
Zheng et al. (2018) | Plasma | lncRNA-PTENP1 | 110 | ExoQuick exosome purification kit | Diagnostic biomarker, predict disease progression | AUC = 74.3%, sensitivity = 65.4%, specificity = 84.2%, predict disease progression (p < 0.05) | [161] |
Yin et al. (2020) | Plasma | miR-663b | 122 | ExoQuick‐TC Exosome Precipitation Solution | Predict disease progression | Disease progression (p < 0.05) | [167] |
Yan et al. (2020) | Plasma | LINC00355 | 57 | miRNA microarray | Predict disease progression | Disease progression (p < 0.05) | [168] |
Cai et al. (2020) | Serum | miR-133b | 11 | Total exosome isolation reagent | Predict disease progression | Disease progression (p < 0.05) | [170] |
Sabo et al. (2020) | Plasma | miR-126-3p | 93 | Deep sequencing | Predict prognosis | OS (p < 0.05) | [171] |
Zhang et al. (2019) | Serum | LINC00355 | 520 | ExoQuick exosome purification kit | Predict prognosis | RFS (p = 0.01) | |
Chen et al. (2020) | Serum | circRNA hsa_circ_0051443 | 592 | FRET, CD spectroscopy | Predict prognosis | OS (p < 0.05) | [181] |
Yang et al. (2022) | Serum | circTRPS1 | 90 | ExoQuick Exosome Precipitation Solution | Predict prognosis | OS (p = 0.01) | [182] |
Chen et al. (2018) | Serum | circRNA-PRMT5 | 119 | Electron microscopy | Predict prognosis | OS (p = 0.028) | [183] |