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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: RPL21 interacts with LAMP3 to promote colorectal cancer invasion and metastasis by regulating focal adhesion formation

Fig. 7

Schematic diagram demonstrating the mechanism of RPL21 and LAMP3 to promote CRC metastasis. The high expression of RPL21 in CRC cells activated the transcriptional function of TFEB to upregulate the expression of LAMP3. The direct interaction between RPL21 and LAMP3 suppressed the ubiquitin–proteasome degradation of RPL21 and activated the FAK/paxillin/ERK signaling pathway to increase the formation of immature FAs, thereby promoting CRC cell migration, invasion, and tumor metastasis

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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