Fig. 1

Dysregulated expression of m6A regulators and elevated KIAA1429 levels were correlated with disease progression in DLBCL. A Heatmap of m6A regulator expression in the healthy tonsil tissues (n = 33) and DLBCL tissues (n = 55) from the GEO database (GSE56315), with high and low expression levels shown in red and blue, respectively. B Survival curves indicated shorter survival times for patients with DHL with higher KIAA1429 expression. C The mRNA level of KIAA1429 in DLBCL cells (n = 3) was increased compared with that in CD19⁺ B cells (n = 3) as determined by RT-qPCR. Data are represented as mean ± SD of three independent experiments. **p < 0.01. D Western blotting indicated enhanced KIAA1429 expression in DLBCL cell lines. E Higher expression of KIAA1429 was found in DLBCL tissues (n = 60) than in RHL samples (n = 20). Bar, 50 μm. F Comparison of MOD values for KIAA1429-positive staining in DLBCL and RHL patients by two-tailed Student’s t-test. ****p < 0.0001. G Survival analysis revealed more prolonged survival times of patients with DLBCL with decreased KIAA1429 expression than those with increased KIAA1429 expression. The median overall survival was assessed by the log-rank test