Fig. 8

KIAA1429 inactivated Hippo–YAP signaling by interacting with CHST11. A YAP was highly expressed in DLBCL tissues (n = 55) compared with healthy tonsil tissues (n = 33) based on the GSE56315 dataset. B–D Knockdown of YAP inhibited cell proliferation promotion, apoptosis reduction, and cell cycle progression acceleration induced by KIAA1429 overexpression. Mean ± SD is presented for three independent experiments. *p < 0.05, **p < 0.01; ***p < 0.001; ****p < 0.0001. E Model of KIAA1429-mediated m6A modification regulating DLBCL progression through the Hippo–YAP pathway