Table 1 MiRNAs and their contribution to the metabolism reprogramming of cancer cells

miR-7

TS

Glioma

Repression of glucose metabolism

Targeting the 3′-UTR of IGF1-R

[16]

miR-143

TS

Lung and colon cancers

Repression of glucose metabolism

Inhibiting HK2

[29, 63]

miR-1291

TS

Renal cell carcinoma, breast and pancreatic cancer

Repression of glucose and lipid metabolisms

Targeting GLUT1, downregulating CPT1C expression

[19, 20]

miR-199a-5p

TS

Non-small cell lung cancer and liver cancer

Repression of the glucose metabolism

Downregulating GLUT 1 and inhibiting HK2 and glycolysis

[64, 65]

miR-199a-3p

TS

Renal cell carcinoma

Repression of the glucose metabolism

Inhibiting Glut1 and glycolysis

[26]

miR-138

TS

Renal cell carcinoma

Repression of the glucose metabolism

Inhibiting Glut1 and glycolysis

miR-150

TS

Renal cell carcinoma

Repression of the glucose metabolism

Inhibiting Glut1 and glycolysis

miR-532-5p

TS

Renal cell carcinoma

Repression of the glucose metabolism

Inhibiting Glut1 and glycolysis

miR-33a/33b

TS

Hepatic cells

Repression of the glucose and lipid metabolisms

Inhibiting G6PC and PCK1

Inhibiting translation of CPT1A, CROT, and HADHB

[48, 66]

miR-122

Oncogene

Breast cancer

HCC

Elevation of glucose metabolism

Elevation of cholesterol metabolism

Targeting PKM2,

Targeting hepatic fatty acid oxidation and inducing cholesterol synthesis

[31, 50]

Let-7a

TS

Glioma

Repression of glucose metabolism

Regulating PKM2 expression

[67]

let-7a-5p

TS

TNBC

Repression of glucose metabolism

Lowering the expression of GLUT12 and inhibiting aerobic glycolysis

[24]

miR-26a

Oncogene

Colorectal cancer cells

Elevation of glucose metabolism

Inhibiting the critical step of glycolysis entry into the TCA cycle by targeting PDHX

[33]

miR-375

TS

Gastric cancer

Esophagus cancer

Repression of glucose metabolism

Targeting PDK1 and suppressing aerobic glycolysis

[68]

miR-23a/b

2009

TS

Prostate cancer cells

Repression of amino acid metabolism

Promoting glutamine metabolism by targeting glutaminase

[56]

miR-664, miR-485-3p,

miR-495

Oncogene

Hepatocellular carcinoma

Repression of amino acid metabolism

Inhibiting MAT1A expression

[58]

miR-181a-5p

Oncogene

Liver cancer

Elevation of glucose metabolism

Reducing the level of MT-CYB and MT-CO2, upregulating HK2 and GLUT1, increasing LDH activity

[39]

miR-155

miR-210

Oncogene

Melanoma

Elevation of glucose metabolism

Increasing aerobic glycolysis and decreasing oxidative phosphorylation

[41]

miR-27a

TS

Colorectal cancer

Repression of glucose and lipid metabolism

Impairing oxidative phosphorylation, reducing TCA cycle and fatty acid β-oxidation through modulation of PGC-1α, CPT1A, ACAD9, citrate synthase, HK1 and HK2, DLAT, the E2 component of the PDH

[43]

miR-342-3p

TS

TNBC

Repression of glucose metabolism

Targeting MCT1 and reducing glycolysis

[45]

miR-146a-5p

miR-155-5p

Oncogene

Renal cancer

Elevation of glucose and amino acid metabolisms

Targeting G6PD and TKT (PPP enzymes)

Targeting SUCLG2 (TCA enzyme), targeting GATM (arginine metabolism enzyme)

[69]

miR-513c

miR-3163

TS

Breast cancer

Repression of amino acid metabolism

Targeting glutamine metabolism, especially glutaminase

[70]