Table 2 LncRNAs and their contribution to the metabolism reprogramming of cancer cells
From: The role of noncoding RNAs in metabolic reprogramming of cancer cells
lncRNA | Oncogene/TS | Cancer | Metabolic reprogramming | Mechanism | Refs. |
|---|---|---|---|---|---|
lincRNA-p21 | TS | Prostate cancer | Repression of glucose metabolism | Inhibiting PKM2 expression, reducing pyruvate production, and inhibiting cell proliferation | [101] |
lncRNA H19 | TS | Ovarian cancer | Elevation of glucose metabolism | Enhancing glucose consumption, lactate production, and PKM2 expression by sponging miR-324-5p | [102] |
TP53TG1 | Oncogenic | Brain tumor cells | Elevation of glucose metabolism | Promotes the expression of glucose metabolism-related genes LDHA and IDH1 | [103] |
MAFG-AS1 | Oncogenic | Colorectal Ccncer | Elevation of glucose metabolism | Sponging miR-147b and activation of NDUFA4, causing an upregulation of PDK1, PFK1, and PKM2 | [104] |
FEZF1-AS1 | Oncogenic | Colorectal cancer | Elevation of glucose metabolism | Binds and increases the stability of PKM2 | [105] |
BCYRN1 | Oncogenic | Non-small cell lung cancer | Elevating glucose metabolism | Increasing the expression levels of PKM2 and inducing glycolysis via the miR-149/PKM2 axis | [106] |
AC020978 | Oncogenic | Non-small cell lung cancer | Elevation of glucose metabolism | Promotion of glycolysis by direct interaction with PKM2 and enhancing PKM2 protein stability Promotes the nuclear translocation of PKM2 and regulate PKM2-enhanced HIF-1α transcription activity | [107] |
LINC00689 | Oncogenic | Glioma | Elevation of glucose metabolism | Promoting glycolysis by sponging of miR-338-3p and increasing PKM2 expression | [108] |
LINC01554 | TS | Liver cancer | Repression of glucose metabolism | Decreasing in PKM2 expression and reduced glycolysis and cancer cell progression | [109] |
SOX2OT | Oncogenic | Liver cancer | Elevation of glucose metabolism | Promoting glycolysis by sponging miR-122-5p and activating PKM2 | [110] |
NEAT1 | Oncogenic | HCC | Elevation of lipid metabolism | Upregulating adipose triglyceride lipase (ATGL) expression and increasing lipolysis | [91] |
lincRNA DYNLRB2-2 | Oncogenic | – | Elevation of lipid metabolism | Upregulating ABCA1 and increasing cholesterol metabolism | [111] |
lncRNA HULC | Oncogenic | HCC | Elevation of lipid metabolism | Overexpression of sphingosine kinase 1, Increasing the synthesis of sphingomyelin | [112] |
HOTAIR | Oncogenic | HCC | Elevation of amino acid metabolism | Upregulation in glutamine metabolism by sponging miR-126-5p to regulate glutaminase | [113] |
CCAT2 | Oncogenic | Variety of cancers | Elevation of amino acid metabolism | Upregulation in glutamine metabolism by the expression of an alternative splicing isoform of GLS (glutaminase isoform C) | [114] |
PCGEM1 | Oncogenic | Prostate cancer | Elevation of amino acid metabolism | Activating c-Myc, regulating PPP, glutamine, and TCA pathways | [78] |