Fig. 1
From: An integrative review of nonobvious puzzles of cellular and molecular cardiooncology
Pathomechanisms of IR-dependent cardio- and vasotoxicity in cardiomyocytes (A), vascular endothelial cells (B), and vascular smooth muscle cells (C). AC acetylation, Me methylation, SM sphingomyelin, OONO− peroxynitrite, aSMase acid sphingomyelinase, PIP3 phosphatidylinositol (3,4,5)-trisphosphate, PLC phospholipase C, DAG diacylglycerol, IP3 inositol 1,4,5-trisphosphate, IP3-R inositol 1,4,5-trisphosphate receptor