Fig. 2

RNA sequencing of mitochondrial dynamics-related and AMPK-related genes. a Gene expression profiles in IRI model mice, empagliflozin-treated IRI mice, and sham mice were obtained by RNA sequencing. The results were visualized as a heat map of gene expression. b The relative expression of Fis1, Mff, OPA1, Mfn1, and Mfn2. c The relative expression of AMPK-related mTOR and FOXO3. The experiments were repeated independently at least three times, and the data were presented as the means ± SEM. Statistical significance with respect to control was marked with *P < 0.05, **P < 0.01 or ***P < 0.001