Fig. 3
From: Notch mediates the glycolytic switch via PI3K/Akt signaling to support embryonic development
Blocking of Notch signaling reduces the hypoxic glycolysis level and the PI3K/Akt signaling in primary hepatocytes. A, B Dose effect of CoCl2 on glucose consumption, lactate production, and ATP levels (A), and the relative mRNA expression and protein abundance of HIF-1α (B) in goose embryonic primary hepatocytes (n = 6). C–I Dose effect of DAPT on Notch signaling (C–F), glucose consumption, lactate production, ATP levels (F), relative mRNA expressions of HK2, PFK, PKM, and LDHA (G), and PI3K/Akt signaling (D, H, and I) in goose embryonic primary hepatocytes (n = 6)