Fig. 5
HK010 shows strong antitumor activity in vivo. A Schematic diagram of HK010 treatment of B-hPD-1/h4-1BB mice bearing MC38/hPD-L1 transplants. When the mean tumor size reached approximately 100 mm3, mice were randomized into groups of eight animals per group. Treatment with HK010 six times (indicated by vertical arrows). The changes in tumor volume (B) and tumor weight (C) of the mice treated with HK010. The values are presented as the mean ± SEM. D Schematic diagram of the MC38/hPD-L1 cell rechallenge experiment after HK010 treatment of B-hPD-1/h4-1BB mice bearing MC38/hPD-L1 transplants. When the mean tumor size reached approximately 150 mm3, mice were randomized into groups of five animals per group. Antibody treatment using HK010 or αPD-L1 plus α4-1BB was performed six times (indicated by vertical arrows), and the changes in tumor volume were compared (E). The values are presented as the mean ± SD from one representative of three independent experiments. **p < 0.01, ***p < 0.001