Fig. 7
HK010 is well tolerated in cynomolgus monkeys. A In the single-dose PK study, HK010 displayed a dose-dependent increase in Cmax and AUClast within the dose range of 2.5–10 mg/kg. B Schematic diagram for the 5 week repeated-dose toxicity study. Cynomolgus monkeys were given IV HK010 treatment (0, 5, 15, and 50 mg/kg) once a week. C No abnormal change in the CD3+ T lymphocyte percentage in the repeated-dose toxicity study. D No abnormal change in blood ALT/AST levels was observed in the repeated-dose toxicity study. M male; F female. Each group had four male and four female cynomolgus monkeys. The values are presented as the mean ± SD