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Table 1 Main pharmacokinetic parameters of HK010 by five intravenous injections (mean ± SD, n = 10)

From: An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity

Time

Dose (mg/kg)

AUClast (h μg/ml)

Cmax (μg/ml)

Tmax (h)

D1

5

9176.1 ± 1426.5

132.4 ± 12.7

0.083–2

15

31,452.1 ± 3108.4

381.5 ± 53.2

0.083–2

50

105,464.1 ± 10,710.5

1203.6 ± 187.5

0.083–24

D29

5

15.0 ± 2.6

13.5 ± 1.6

0.083

15

10,152.1 ± 14,821.3

212.3 ± 199.3

0.083–2

50

113,820.4 ± 86,091.3

1371.8 ± 439.7

0.083–24

  1. AUClast area under the serum drug concentration–time curve to the last measurable serum concentration; Cmax maximum drug concentration observed in the serum; Tmax time of the first occurrence of Cmax
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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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