Fig. 2From: The NLRP3 inflammasome: contributions to inflammation-related diseasesNoncanonical activation of the NLRP3 inflammasome. LPS can induce noncanonical activation of the NLRP3 inflammasome. LPS enters the cytoplasm by endocytosis or transfection, and then binds and activates pro-caspase-11, which subsequently cleaves GSDMD to promote pyroptosis, and activates the NLRP3 inflammasomeBack to article page