Fig. 4
tRFTyr could specifically bind to LDHA in LSCC. A The Venn diagram indicates the number of tsRNAs in tRFTyr pulldown analysis. B The top ten pathways of 317 tRFTyr-specific binding proteins. C Histograms of quantitative analysis of LDHA peptides in each subgroup of PRM analysis. D Qualitative peak spectrum analysis for the LDHA peptides. E RIP assay demonstrated that tRFTyr was abundantly enriched in the LDHA group compared with the IgG group. F The expression of LDHA in various oncologic tissues compared with adjacent normal tissue based on GEPIA. G The overall survival of LDHA in HNSC based on GEPIA. H Representative immunohistochemical staining of LDHA at different intensities in 60 LSCC tissues. I Kaplan–Meier overall survival analysis of LDHA expression in 60 pairs of laryngeal carcinoma tissues. J The relative expression of lactate in LSCC samples by LC–MS (C: LSCC tissues, N: adjacent normal tissues). K Pearson correlation analysis indicated the relation between tRFTyr and LDHA expression