Fig. 1

HOPE improves liver function and reduces inflammation in a rat model of DCD. A, B The levels of AST and ALT in the perfusate (n = 6 for each group). C, D H&E staining and histological injury score in rat liver tissue (n = 6 for each group). Scale = 200 μm (top panel) and 50 μm (bottom panel). E–L mRNA expression levels of IL-1β, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ, and HMGB1 (n = 3 for each group). ^*p < 0.05 and ^** p < 0.01