Fig. 5

HOPE attenuates ER stress and apoptosis by activating JAK2/STAT3 pathway in a rat model of DCD. A–F Western blotting and statistical analyses of BIP, CHOP, ATF6, ATF4, IRE1, p-IRE1, XBP-1s, BCL2, BAX, PUMA, NOXA, GADD45A, caspase-9, caspase-3, and β-actin proteins (n = 3 for each group). p-IRE1 indicates phospho-IRE1, T-caspase indicates total caspase, C-caspase indicates cleaved caspase. G Caspase-3 activity detection (n = 6 for each group). H, I TUNEL staining and scoring of rat liver tissue (n = 6 for each group). Scale = 200 μm. ^*p < 0.05 and ^**p < 0.01