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Fig. 8 | Cellular & Molecular Biology Letters

Fig. 8

From: Hypothermic oxygenated perfusion attenuates DCD liver ischemia–reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress

Fig. 8

Schematic showing proposed mechanism. HOPE inhibits the three branches of UPR (PERK, ATF6, and IRE1 pathways) by activating JAK2/STAT3 signal pathway, thus alleviating ER stress and apoptosis. In addition, activated JAK2/STAT3 signal pathway can maintain ER calcium homeostasis by upregulating HAX1 and promoting the interaction of HAX1/SERCA2b. Upregulated HAX1 also regulates ER stress and apoptosis by inhibiting the IRE1 pathway

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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