Fig. 4

The phenotype of GZMA in osteoclasts was rescued by miR-25-3p. A The inhibitory effect of GZMA crRNA1/Cas13d on osteoclast cell proliferation was rescued obviously by miR-25-3p inhibitor. B The promotion of caspase-3 activities in GZMA crRNA1/Cas13d group was reversed dramatically by the suppression of miR-25-3p. C The increase of apoptosis rate was also reversed significantly by transfection of miR-25-3p inhibitor using flow cytometry assay. *Means P < 0.05, ** means P < 0.01