Fig. 2

NanoString gene expression analyses of the brain tissues from the male offspring of pregnant mice exposed to LPS. A After prenatal exposure to 25 µg/kg LPS, the gene scores for neurotransmissions slightly decreased and those for oligodendrocytes and oligodendrocyte function increased in the prefrontal cortex (pfc) and hippocampus (hippo) tissues of the male offspring. Lipid metabolism gene scores increased in the tissues from the prefrontal cortex of the male offspring but not in those from their hippocampus after prenatal exposure to 25 µg/kg LPS. The gene scores of neurons, neurotransmitters, astrocytes, astrocyte function, oligodendrocytes and oligodendrocyte function, microglia, microglia function, carbohydrate metabolism and lipid metabolism in the prefrontal cortex and hippocampus tissues of the male offspring were affected by prenatal exposure to 25 µg/kg LPS. B mRNA expression of selected genes involved in lipid metabolism in the NanoString gene profiling assay. Data are presented as means ± SEM. * P < 0.05 versus 0 µg/kg LPS by one-way ANOVA with the Tukey’s multiple comparisons test