Table 1 Genes upregulated after DSC1 overexpression both on protein (q-value < 0.05, log2 FC > 0.58) and mRNA level (q-value < 0.05, log2 FC > 1)

DSC1

Q08554

Desmocollin-1

4.98E−49

6.21E−129

− 0.52

3.31E−28

− 1.19

− 1.38

2.07E−40

1.53E−70

IGFBP5

P24593

Insulin-like growth factor-binding protein 5

2.92E−04

2.76E−40

− 2.50

0.014

− 1.01

− 2.27

0.089

4.08E−111

MYO5C

Q9NQX4

Unconventional myosin-Vc

1.10E−03

2.76E−68

− 0.36

0.010

− 0.58

0.02

3.40E−03

2.34E−74

SPPL2A

Q8TCT8

Signal peptide peptidase-like 2A

3.83E−04

3.40E−67

− 0.21

0.141

− 0.46

0.27

1.83E−03

6.81E−71

SLC27A2

O14975

Very long-chain acyl-CoA synthetase

1.17E−08

3.52E−14

− 0.55

7.61E−05

− 0.88

− 1.24

2.03E−07

7.14E−32

USP8

P40818

Ubiquitin carboxyl-terminal hydrolase 8

7.99E−07

6.02E−48

0.24

5.70E−05

0.45

0.38

3.92E−11

2.86E−53

FREM2

Q5SZK8

FRAS1-related extracellular matrix protein 2

2.20E−14

1.07E−22

2.28

1.14E−06

3.59

− 1.67

0.131

1.61E−32

RHOB

P62745

Rho-related GTP-binding protein RhoB

1.17E−07

7.28E−10

− 0.55

1.26E−06

0.12

0.46

2.52E−04

0.017

TMOD3

Q9NYL9

Tropomodulin-3

8.46E−16

1.90E−45

0.16

1.42E−03

0.29

0.00

2.21E−14

1.40E−58

TOM1L1

O75674

TOM1-like protein 1

1.01E−06

1.16E−21

0.11

7.91E−03

0.18

− 0.17

1.38E−04

3.87E−25

FKBP10

Q96AY3

Peptidyl-prolyl cis–trans isomerase FKBP10

0.013

7.16E−14

− 0.46

0.021

− 0.67

− 1.44

0.017

1.65E−30

CKMT1A

P12532

Creatine kinase U-type, mitochondrial

7.41E−07

1.47E−06

− 0.41

2.53E−03

− 0.67

0.01

8.28E−09

4.75E−04

LXN

Q9BS40

Latexin

2.51E−12

1.01E−65

− 0.33

1.39E−03

0.20

1.21

8.17E−06

6.06E−66

MYO5A

Q9Y4I1

Unconventional myosin-Va

7.98E−05

5.19E−33

− 0.06

0.125

− 0.38

0.49

2.42E−04

2.39E−44

LMCD1

Q9NZU5

LIM and cysteine-rich domains protein 1

1.40E−03

1.44E−13

0.26

8.84E−03

0.59

1.59

0.011

1.57E−14