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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway

Fig. 3

Inhibition of UGCG expression ameliorated heart hypertrophy and heart fibrosis. A–C mRNA levels of ANP, BNP, and β-MHC in hearts from different groups (N = 6). D–G Western blot results of Col1, ANP, BNP expression levels in hearts from different groups (N = 3). H, J HE staining showed the cell surface area of cardiomyocytes from different groups (N = 6). I, K Immunohistochemical images of α-SMA staining in heart fibroblasts from different groups (N = 6). L, N Western blot results of ANP and BNP expression levels in cardiomyocytes from different groups (N = 3). *p < 0.05. AAV-Scramble: Negative control of AAV-Sh-UGCG; Ad-Scramble: Negative control of Ad-Sh-UGCG; ANP: Atrial natriuretic peptide; BNP: Brain natriuretic peptide; β-MHC: β-myosin heavy chain; Col1: Collagen I; Ad: Adenovirus; TGF-β: Transforming growth factor-beta

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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