Table 2 Univariate and multivariate analyses of different prognostic parameters of the CRC patients in the cohort
Factor | Univariate analysis | p-Value | Multivariate analysis | p-Value |
|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
Age (≤ 60/ > 60) | 0.615 (0.395–0.957) | 0.031 | 2.203 (1.387–3.497) | 0.001 |
Gender (female/male) | 0.854 (0.546–1.335) | 0.488 |  |  |
Location (colon/rectum) | 0.682 (0.374–1.245) | 0.212 |  |  |
T stage (T1 + T2/T3 + T4) | 0.176 (0.069–0.446) |  < 0.001 |  |  |
N stage (N0/N1 + N2) | 0.293 (0.163–0.524) |  < 0.001 |  |  |
Distant metastasis (absent/present) | 0.083 (0.042–0.167) |  < 0.001 | 12.138 (6.024–24.458) |  < 0.001 |
TNM stage (I + II/ III + IV) | 0.171 (0.078–0.375) |  < 0.001 |  |  |
Histological grade (well + moderate/poor) | 0.450 (0.277–0.733) | 0.001 | 1.995 (1.196–3.327) | 0.008 |
Vein invasion (no/yes) | 0.647 (0.386–1.085) | 0.099 |  |  |
Nerve invasion (no/yes) | 0.503 (0.317–0.796) | 0.003 |  |  |
Tumor size (≤ 5/ > 5 cm) | 0.663 (0.416–1.055) | 0.083 |  |  |
MCCC2 expression (low/high) | 1.661 (1.067–2.586) | 0.025 |  |  |