Fig. 3
From: N6-methyladenosine modification—a key player in viral infection
Schematic representation of m6A modification in RNA virus infection. A METTL3 promotes m6A modification of SARS-CoV-2 RNA and proviral gene expression. METTL3 inhibits innate immune signaling effector molecule RIG-I binding to SARS-COV-2 RNA. METTL3 interacts with the N region of RdRp (a viral RNA polymerase), and RdRp inhibits the sumoylation and ubiquitination modifications of METTL3 through posttranscriptional modifications. B The m6A writers METTL3 or METTL14 promote Gag protein expression and the level of capsid p24 release. YTHDF1-3 proteins bind with HIV-1 RNA to negatively regulate HIV-1 post-entry infection by blocking viral reverse transcription in CD4+ T cells