Fig. 1

Srg3 is highly expressed in sepsis-induced lung injury. A Histopathology of lung tissues from rats examined by H&E staining. B Proportions of glycogen in lung tissues of rats examined by PAS staining. C Numbers of various immune cells in bronchoalveolar lavage fluid (BALF) of rats analyzed by flow cytometry. D Levels of inflammatory factors in BALF of rats detected by ELISA. E Permeability of blood vessels in lung tissues of rats examined by EB staining. F Intensity of Spc-1 staining in lung tissues of rats examined by IHC staining. G Proportions of apoptotic cells in lung tissues of rats examined by TUNEL staining. H, I Differential gene expression analysis of lung tissues between control and sepsis-induced rats using RNA-seq. J, K mRNA and protein expression levels of Srg3 in lung tissues of rats detected by qPCR and WB, respectively. L Intensity of Srg3 staining in lung tissues of rats examined by IHC staining. Each group contained six rats, with each point representing one rat. Significant differences were detected using one-way ANOVA and Tukey’s multiple comparison test, **P < 0.01, ***P < 0.001, ***P < 0.0001