Metabolite itaconate in host immunoregulation and defense

Table 2 The role of itaconate and derivatives in cancer

Disease	Model	Agents	Mechanisms	Role	Reference
Colorectal cancer	DSS-induce mice model	DI	Inflammatory cytokine	Antitumor effect	Wang et al.
Peritoneal tumors	Peritoneal tumors-bearing mice	IRG1 deletion	OXPHOS, ROS, MAPK	Prompt tumor growth	Weiss et al.
Glioma	Xenograft transplantation model	IRG1 knockdown	Cell cycle regulatory proteins	Prompt tumor growth	Pan et al.
Retinoblastoma	Xenograft mouse models	4-OI	Ferroptosis	Antitumor effect	Liu et al.
Thymic carcinoma	Cell line Ty82	DI	LDHA-mTOR axis	Antitumor effect	Hayashi et al.
Hepatocellular carcinoma	Diethylnitrosamine-induced HCC	DI	Mitochondrial apoptosis	Antitumor effect	Gautam et al.
Breast cancer	Allografted tumors	IRG1 deletion	CD8⁺ T cells	Prompt tumor growth	Zhao et al.

ISSN: 1689-1392