Fig. 1From: Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s diseaseAlzheimer’s Brain (Disintegrating Microtubule). The transmembrane amyloid precursor protein is cleaved by proteases to produce the β-amyloid (Aβ) peptides that make up the majority of the deposits that make up amyloid plaques (APP). The bulk of NFTs are composed of aggregates of hyperphosphorylated tau proteinBack to article page