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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease

Fig. 2

Cleavage of amyloid precursor protein (APP). Aβ-peptides, which are sequentially released from the amyloid precursor protein (APP) by β- and γ-secretase, are responsible for amyloid plaques. In addition, α-secretase and γ-secretase can sequentially cleave APP, yielding non-amyloidogenic fragments. Since APP and β-secretase are primarily expressed in neurons, most Aβ is produced in neurons

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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