Fig. 5

The erythropoietic system of Alox15-KI mice is compromised. A–F Erythrocyte parameters of Alox15-KI mice and outbred wildtype controls were determined in two age categories (young mice, 10–20 weeks; aged mice, 70–75 weeks, n = 6 for each age-group, Mann–Whitney U-test. ns, not significant, *p < 0.05, **p < 0.01.). Additional hematological parameters are given in Additional file 1: Fig. S6, S7. G–J Osmotic stability of erythrocytes: the osmotic stability of red blood cells in the two age categories (young mice, 10–20 weeks; aged mice, 70–75 weeks, n > 3 for each age-group) were determined as described in the Additional file 1. The degree of hemolysis was calculated at each NaCl concentration. Hemolysis curves were compared with two-way ANOVA