From: Role of N6-methyladenosine methylation in glioma: recent insights and future directions
Regulators | Roles in nervous system regulation | Related targets | References |
---|---|---|---|
METTL3 | ↑Proliferation of NSCs | ↑Ezh2 | [27] |
↑Cortical neurogenesis |  | [29] | |
↑Cerebellar development | ↓Atoh1, Cxcr4, Notch2 | [35] | |
↑Long-term memory formation | ↑IEGs | [36] | |
METTL14 | ↑Proliferation of NSCs | ↓CBP, p300 | [28] |
↓Premature differentiation of NSCs | ↓CBP, p300 | [28] | |
↑Cortical neurogenesis |  | [30] | |
↑Acquisition of response learning and reversal learning | ↑striatal mRNAs encoding neuron- and synapse-specific protein | [37] | |
↑Axon regeneration | ↑De novo gene | [44] | |
FTO | ↑Proliferation and neuronal differentiation of aNSCs | ↑PDGFRA/SOCS5-STAT3 | [32] |
↓Neuronal apoptosis | ↑BDNF | [33] | |
↓Synaptic plasticity | ↓ADRB2 / c-MYC / SIRT1 | [39] | |
↑Neuronal signaling | ↑DA signaling pathway | [41] | |
↑Hippocampal neurogenesis and cellular differentiation | ↓HPA axis | [42] | |
↑Axon elongation | ↑GAP-43 | [43] | |
ALKBH5 | ↑Cerebellar development | ↓Mphosph9 | [34] |
YTHDF1 | ↑long-term synaptic plasticity | ↑GRIN1, GRIN2A, GRIA1, CAMK2A, CAMK2B | [38] |
↑axon regeneration | ↑De novo gene | [44] |